Genetic and pathogenic overlaps between autism and Alzheimer’s disease: opportunities for drug repurposing
Authors: Ekaterina Trifonova
Conference: Autism Challenges and Solutions – XII 2024
Keywords: Autism spectrum disorder (ASD) , neurodegenerative disorders, Genetic
Abstract
Autism spectrum disorder (ASD) and Alzheimer’s disease (AD) are neurodevelopmental and neurodegenerative disorders respectively that share common clinical features, such as language impairment, executive functions, and cognitive problems. Proteomic analysis of autism and Alzheimer’s mouse models reveal common alterations in mTOR signaling pathway. Alterations in the mTOR signaling pathway during critical stage of development could lead to improper connectivity in the brain, which play a role in the pathogenesis of ASD. At the same time mTOR inhibitor rapamycin has been shown to prevent (and possibly restore in some cases) the memory deficit in the mouse model of Alzheimer’s disease as well as reduce Aβ and tau aggregation, and reduce microglia activation. We conducted a bioinformatic analysis of signaling pathways for sets of genes for ASD and Alzheimer’s disease: sets of genes predisposing to ASD (from the SFARI database) and to AD have 148 common genes, 75 of them are directly related to mTOR. We have constructed and analyzed gene networks reflecting the relationship of ASD and AD with innate immunity and autoimmune diseases. The genes with the largest number of connections have been identified: CTNNB1, CREBBP, TRAF2, HDAC1, HDAC2, etc., which may be targets for therapy. Based on a large percentage of mTOR-related ASD and AD genes, we searched for mTOR molulators used in AD therapy with potential for ASD therapy. To do this, using ANDVisio tools, networks were built based on three fragments of the mTOR path: PI3K/Akt, Ras and p38 MAPK. We have proposed several pharmacological mTOR modulators already used in AD therapy, which have the potential for ASD.
I was recommended this website by my cousin I am not sure whether this post is written by him as nobody else know such detailed about my difficulty You are wonderful Thanks.
Hi! Do you know if they make any plugins to assist with SEO? I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good success. If you know of any please share. Cheers!
I was looking through some of your blog posts on this internet site and I believe this site is really informative! Retain posting.
Thank you for sharing superb informations. Your site is so cool. I’m impressed by the details that you have on this website. It reveals how nicely you perceive this subject. Bookmarked this website page, will come back for more articles. You, my pal, ROCK! I found just the information I already searched everywhere and just couldn’t come across. What a perfect web-site.
I’m still learning from you, while I’m making my way to the top as well. I absolutely liked reading all that is posted on your blog.Keep the aarticles coming. I enjoyed it!
Hey very nice web site!! Man .. Excellent .. Amazing .. I will bookmark your website and take the feeds also…I’m happy to find numerous useful information here in the post, we need work out more strategies in this regard, thanks for sharing. . . . . .
Wow! This blog looks just like my old one! It’s on a completely different subject but it has pretty much the same page layout and design. Excellent choice of colors!
Very efficiently written article. It will be helpful to everyone who usess it, including me. Keep up the good work – looking forward to more posts.
Valuable info. Lucky me I found your website by accident, and I’m shocked why this accident didn’t happened earlier! I bookmarked it.
I keep listening to the news bulletin speak about receiving boundless online grant applications so I have been looking around for the most excellent site to get one. Could you advise me please, where could i acquire some?
Thankyou for helping out, superb information.
As a Newbie, I am always exploring online for articles that can aid me. Thank you
I am curious to find out what blog system you have been using? I’m having some small security problems with my latest site and I would like to find something more safe. Do you have any recommendations?
I have read several excellent stuff here. Certainly price bookmarking for revisiting. I surprise how so much attempt you set to make this sort of great informative web site.
I am lucky that I found this web site, precisely the right information that I was searching for! .
Keep functioning ,impressive job!
I would like to thank you for the efforts you’ve put in writing this blog. I’m hoping the same high-grade website post from you in the upcoming also. Actually your creative writing skills has encouraged me to get my own website now. Actually the blogging is spreading its wings fast. Your write up is a good example of it.
Magnificent website. Lots of helpful info here. I am sending it to some friends ans also sharing in delicious. And certainly, thank you in your effort!
It is in reality a nice and helpful piece of info. I am happy that you just shared this useful info with us. Please stay us informed like this. Thanks for sharing.
Hello, i think that i saw you visited my site so i got here to “go back the prefer”.I’m trying to find issues to enhance my web site!I suppose its ok to use a few of your ideas!!
Thank you for sharing superb informations. Your site is so cool. I am impressed by the details that you have on this site. It reveals how nicely you perceive this subject. Bookmarked this web page, will come back for more articles. You, my pal, ROCK! I found just the information I already searched all over the place and simply could not come across. What a great site.
Great – I should certainly pronounce, impressed with your web site. I had no trouble navigating through all tabs as well as related information ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, website theme . a tones way for your customer to communicate. Excellent task..
Excellent blog here! Also your site loads up very fast! What host are you using? Can I get your affiliate link to your host? I wish my site loaded up as quickly as yours lol
Hello.This post was extremely fascinating, particularly since I was browsing for thoughts on this matter last week.
The other day, while I was at work, my cousin stole my iPad and tested to see if it can survive a thirty foot drop, just so she can be a youtube sensation. My apple ipad is now broken and she has 83 views. I know this is totally off topic but I had to share it with someone!
The subsequent time I read a blog, I hope that it doesnt disappoint me as a lot as this one. I mean, I know it was my option to read, but I really thought youd have something fascinating to say. All I hear is a bunch of whining about one thing that you might repair for those who werent too busy searching for attention.
You are my breathing in, I possess few web logs and very sporadically run out from to brand : (.
UID_12835053###
test aje nieeeeee
Với 10 năm kinh nghiệm, RAYBET hợp tác với nhiều sự kiện lớn, đảm bảo an toàn, ổn định và rút tiền nhanh chóng, mang đến môi trường cá cược công bằng và tiện lợi cho người chơi.
I’m not that much of a internet reader to be honest but your sites really nice, keep it up! I’ll go ahead and bookmark your site to come back later. Cheers
Some times its a pain in the ass to read what people wrote but this internet site is really user pleasant! .
Good ?V I should definitely pronounce, impressed with your web site. I had no trouble navigating through all tabs and related information ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or anything, web site theme . a tones way for your customer to communicate. Excellent task..
Trải nghiệm cá cược esports đỉnh cao tại Ray Esports – nơi bạn có thể đặt cược trực tiếp vào các giải đấu lớn của LMHT, Dota 2, CS:GO, Valorant, PUBG Mobile và nhiều tựa game khác.
Thanks for a marvelous posting! I quite enjoyed reading it, you might be a great author.I will always bookmark your blog and will eventually come back down the road. I want to encourage you to ultimately continue your great work, have a nice morning!
UID_49633525###
test
UID_41668909###
test